Lipids as mediators of chondrogenesis

Surface Lipids as Multifunctional Mediators of Skin Responses to Environmental Stimuli

Skin surface lipid (SSL) film is a mixture of sebum and keratinocyte membrane lipids, protecting skin from environment. Its composition is unique for the high percentage of long chain fatty acids, and of the polyterpenoid squalene, absent in other human tissues, and in non-human Primates sebum. Here, the still incomplete body of information on SSL as mediators of external chemical, physical, an...

Playing "telephone": bioactive lipids as mediators of intercompartmental communication in the alveolus.

The Role of Lipids Mediators in Inflammation and Resolution

1Departamento de Cĺınica Médica, Laboratorio de Imunofarmacologia Experimental (LIFE), Instituto de Ciências da Saúde, Universidade Federal do Triangulo Mineiro (UFTM), Rua Vigário Carlos 162, 38025-350 Uberaba, MG, Brazil 2Faculdade de Ciencias Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, 14049-903 São Paulo, SP, Brazil 3Pulmonary, Critical Care, Sleep and Allergy Medicine, Univ...

Vinculin functions as regulator of chondrogenesis.

To identify the genes involved in chondrocytic differentiation, we applied gene trap mutagenesis to a murine mesenchymal chondrogenic cell line ATDC5 and isolated a clone in which the gene encoding vinculin was trapped. The trapped allele was assumed to express a fusion protein containing a truncated vinculin lacking the tail domain and the geo product derived from the trap vector. The truncate...

Chemokines as mediators of angiogenesis.

Chemokines were originally described as cytokines that mediate leukocyte recruitment to sites of inflammation. Members of a subgroup of chemokines, the CXC family, also play a critical role in both physiologic and pathologic angiogenesis, including in the context of chronic inflammation, fibrosis, and malignancy. A unique feature of this family of cytokines is that, on the basis of their struct...